Occurrence of Carcinogens and their Potential Effects on Human Health – A Review
DOI:
https://doi.org/10.56919/usci.2431.015Keywords:
Cancer, Carcinogenic agents, Genotoxic substance, Malignant cell, Neoplasia, OnchologyAbstract
The significant rise in cancer incidence and related deaths makes cancer one of the biggest threats to public health. Each year, there are about 10 million new cases of cancer and 6 million resultant deaths. In compliance with the disease triangle, the etiology of human cancer can be successfully traced to different environmental sources. Humans are continuously exposed to a wide range of different cancer-causing agents called carcinogens, such as household cleaners, solvents, pesticides, food additives, polluted air or environment, and other products. The Classification of Human Cancer by the International Agency for Research on Cancer (IARC) Monograph series was used as the primary data source for this review. We listed the cancer sites related to each agent based on the IARC review. Sources of these carcinogens were further grouped into classes in the IARC monograph. Home chemicals, environmental pollutants, occupational environments, environmental or medical radioactivity, drugs, microorganisms, contaminated air, and nutritional and behavioral choices are the sources of human exposure to carcinogens. The degree and frequency of exposure to carcinogens have a significant impact on their ability to cause cancer. The knowledge of carcinogens is crucial to creating awareness of cancer and advising the masses to reduce exposure to some environmental substances that are liable to cause cancer.
References
Aggarwal, S., Verma, S. S., Aggarwal, S., & Gupta, S. C. (2021, January). Drug repurposing for breast cancer therapy: Old weapon for new battle. In Seminars in cancer biology (Vol. 68, pp. 8-20). Academic Press.https://doi.org/10.1016/j.semcancer.2019.09.012
Aljamali, N. M., Al-Qraawy, W. K. N., &Helal, T. A. (2022). Review on carcinogens materials in chemical laboratories. International Journal of Molecular Biology and Biochemistry, 4(1), 17-25.https://doi.org/10.33545/26646501.2022.v4.i1a.26
Bellamri, M., Walmsley, S. J., &Turesky, R. J. (2021). Metabolism and biomarkers of heterocyclic aromatic amines in humans. Genes and Environment, 43(1), 1-32.
https://doi.org/10.1186/s41021-021-00200-7
Bhatia, K., & Das, A. (2020). Combinatorial drug therapy in cancer-New insights. Life Sciences, 258, 118134.https://doi.org/10.1016/j.lfs.2020.118134
Birkett, N., Al-Zoughool, M., Bird, M., Baan, R. A., Zielinski, J., &Krewski, D. (2019). Overview of biological mechanisms of human carcinogens. Journal of Toxicology and Environmental Health, Part B, 22(7-8), 288-359.https://doi.org/10.1080/10937404.2019.1643539
Carbone, M., Arron, S. T., Beutler, B., Bononi, A., Cavenee, W., Cleaver, J. E., ...& Yang, H. (2020). Tumour predisposition and cancer syndromes as models to study gene-environment interactions. Nature Reviews Cancer, 20(9), 533-549.https://doi.org/10.1038/s41568-020-0265-y
Cui, H., Wen, J., Yang, L., & Wang, Q. (2022). Spatial distribution of heavy metals in rice grains and human health risk assessment in Hunan Province, China. Environmental Science and Pollution Research, 1-12.https://doi.org/10.1007/s11356-022-21636-6
Danho, S., Thorgrimson, J., &Saary, J. (2022). Effects of Space Radiation on Mammalian Cells. In Handbook of Space Pharmaceuticals (pp. 371-388). Springer, Cham.https://doi.org/10.1007/978-3-030-05526-4_25
Das, S., Kundu, M., Jena, B. C., &Mandal, M. (2020). Causes of cancer: physical, chemical, biological carcinogens, and viruses. In Biomaterials for 3D Tumor Modeling (pp. 607-641). Elsevier.
https://doi.org/10.1016/B978-0-12-818128-7.00025-3
De Martel, C., Georges, D., Bray, F., Ferlay, J., & Clifford, G. M. (2020). Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. The Lancet Global Health, 8(2), e180-e190. https://doi.org/10.1016/S2214-109X(19)30488-7
Deng, H., Muthupalani, S., Erdman, S., Liu, H., Niu, Z., Wang, T. C., & Fox, J. G. (2022). Translocation of Helicobacter hepaticus synergizes with myeloid-derived suppressor cells and contributes to breast carcinogenesis. Oncoimmunology, 11(1),2057399. https://doi.org/10.1080/2162402X.2022.2057399
Dheilly, N. M., Ewald, P. W., Brindley, P. J., Fichorova, R. N., & Thomas, F. (2019). Parasite-microbe-host interactions and cancer risk. PLoS Pathogens, 15(8), https://doi.org/10.1371/journal.ppat.1007912
Dolan, L., Smith, K. S., Marlin, M. B., Bell, L. N., Blythe, E., Greene, M. W., &Frugé, A. D. (2021). Food security, obesity, and meat-derived carcinogen exposure in US adults. Food and Chemical Toxicology, 155, 112412. https://doi.org/10.1016/j.fct.2021.112412
Elgarahy, A. M., Elwakeel, K. Z., Mohammad, S. H., &Elshoubaky, G. A. (2021). A critical review of biosorption of dyes, heavy metals and metalloids from wastewater as an efficient and green process. Cleaner Engineering and Technology, 4, 100209.https://doi.org/10.1016/j.clet.2021.100209
Fatiregun, O. A., Bakare, O., Ayeni, S., Oyerinde, A., Sowunmi, A. C., Popoola, A., ...& Joseph, A. (2020). 10-Year Mortality Pattern Among Cancer Patients in Lagos State University Teaching Hospital, Ikeja, Lagos. Frontiers in Oncology, 10, 36.https://doi.org/10.3389/fonc.2020.573036
Gerba, C. P. (2019). Environmental toxicology. In Environmental and pollution science (pp. 511-540). Academic Press. https://doi.org/10.1016/B978-0-12-814719-1.00028-8
Gissela Borrego-Soto, Rocío Ortiz-López and Augusto Rojas-Martínez (2015) Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer Genetics and Molecular Biology, Volume: 38, Issue: 4 https://doi.org/10.1590/S1415-475738420150019
Goodall, G. J., &Wickramasinghe, V. O. (2021). RNA in cancer. Nature Reviews Cancer, 21(1), 22-36. https://doi.org/10.1038/s41568-020-00306-0
IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 100, A Review of Human Carcinogens. Lyon, France: International Agency for Research on Cancer; 2019. http://monographs.iarc.fr/ENG/ Monographs/PDFs/index.php. Accessed December 2, 2022. 2. IARC.
Karamertzanis, P. G., Atlason, P., Nathanail, A. V., Provoost, J., Karhu, E., &Rasenberg, M. (2019). The impact on classifications for carcinogenicity, mutagenicity, reproductive and specific target organ toxicity after repeated exposure in the first ten years of the REACH regulation. Regulatory Toxicology and Pharmacology, 106, 303-315.
https://doi.org/10.1016/j.yrtph.2019.05.003
Kassim, R., Osei, E., & Cronin, K. A. (2020). A review of the effects of tobacco smoking on cancer treatment: smoking cessation intervention should be integrated into the cancer care continuum. Journal of Radiotherapy in Practice, 19(1), 84-92.
https://doi.org/10.1017/S1460396919000360
Katerji, M., &Duerksen-Hughes, P. J. (2021). DNA damage in cancer development: special implications in viral oncogenesis. American Journal of Cancer Research, 11(8), 3956.
Kayamba, V., & Kelly, P. (2022). Environmental factors associated with gastric carcinogenesis. Current Opinion in Gastroenterology, 38(2), 156-161.
https://doi.org/10.1097/MOG.0000000000000812
Kocarnik, J. M., Compton, K., Dean, F. E., Fu, W., Gaw, B. L., Harvey, J. D., ...&Dhimal, M. (2022). Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis for the Global Burden of Disease Study 2019. JAMA oncology, 8(3), 420-444. https://doi.org/10.1001/jamaoncol.2021.6987
Lawson, J. S., & Glenn, W. K. (2022). Mouse Mammary Tumour Virus (MMTV) in Human Breast Cancer-The Value of Bradford Hill Criteria. Viruses, 14(4), 721.
https://doi.org/10.3390/v14040721
Lewandowska, A. M., Rudzki, M., Rudzki, S., Lewandowski, T., &Laskowska, B. (2019). Environmental risk factors for cancer-review paper. Annals of Agricultural and Environmental Medicine, 26(1). https://doi.org/10.26444/aaem/94299
Libera, J., Iłowiecka, K., &Stasiak, D. (2021). Consumption of processed red meat and its impact on human health: A review. International Journal of Food Science & Technology, 56(12), 6115-6123. https://doi.org/10.1111/ijfs.15270
Liu, X. (2020). Exposure to Carcinogens and its Effects in the Formation of Cancer. J Cancer Res Immunooncol, 6, 123
Loomis, D., Guha, N., Hall, A. L., &Straif, K. (2018). Identifying occupational carcinogens: an update from the IARC Monographs. Occupational and environmental medicine, 75(8), 593-603. https://doi.org/10.1136/oemed-2017-104944
Machlowska, J., Baj, J., Sitarz, M., Maciejewski, R., &Sitarz, R. (2020). Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. International journal of molecular sciences, 21(11), 4012. https://doi.org/10.3390/ijms21114012
Marchese, S., Polo, A., Ariano, A., Velotto, S., Costantini, S., &Severino, L. (2018). Aflatoxin B1 and M1: Biological properties and their involvement in cancer development. Toxins, 10(6), 214. https://doi.org/10.3390/toxins10060214
Murphy, R. A. (2022). Diet, Physical Activity, and Cancer Prevention. In Nutrition Guide for Physicians and Related Healthcare Professions (pp. 149-158). Humana, Cham. https://doi.org/10.1007/978-3-030-82515-7_14
National Cancer Institute (https://www.cancer.gov)
Pakharukova, M. Y., Zaparina, O., Hong, S. J., Sripa, B., &Mordvinov, V. A. (2021). A comparative study of Helicobacter pylori infection in hamsters experimentally infected with liver flukes Opisthorchisfelineus, Opisthorchisviverrini, or Clonorchissinensis. Scientific reports, 11(1), 1-9. https://doi.org/10.1038/s41598-021-87446-x
Piscione, M., Mazzone, M., Di Marcantonio, M. C., Muraro, R., &Mincione, G. (2021). Eradication of Helicobacter pylori and gastric cancer: a controversial relationship. Frontiers in Microbiology, 12, 630852. https://doi.org/10.3389/fmicb.2021.630852
Rae, J. C., Craig, L., Slone, T. W., Frame, S. R., Buxton, L. W., & Kennedy, G. L. (2015). Evaluation of chronic toxicity and carcinogenicity of ammonium 2, 3, 3, 3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in Sprague-Dawley rats. Toxicology reports, 2, 939-949. https://doi.org/10.1016/j.toxrep.2015.06.001
Rahman, M. M., Islam, M. R., Shohag, S., Ahasan, M. T., Sarkar, N., Khan, H., ...&Rauf, A. (2022). Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies. Biomedicine & Pharmacotherapy, 149, 112898.https://doi.org/10.1016/j.biopha.2022.112898
Rietjens, I. M., Michael, A., Bolt, H. M., Siméon, B., Andrea, H., Nils, H., ...& Gerhard, E. (2022). The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment. Archives of Toxicology, 1-56. https://doi.org/10.1007/s00204-022-03242-0
Rifai, L., & Saleh, F. A. (2020). A review on acrylamide in food: Occurrence, toxicity, and mitigation strategies. International Journal of Toxicology, 39(2), 93-102. https://doi.org/10.1177/1091581820902405
Sawicki, T., Ruszkowska, M., Danielewicz, A., Niedźwiedzka, E., Arłukowicz, T., &Przybyłowicz, K. E. (2021). A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis. Cancers, 13(9), 2025. https://doi.org/10.3390/cancers13092025
Schlosser, S., Rabinovitch, R., Shatz, Z., Galper, S., Shahadi-Dromi, I., Finkel, S., ...& Ben-David, M. A. (2020). Radiation-associated secondary malignancies in BRCA mutation carriers treated for breast cancer. International Journal of Radiation Oncology* Biology* Physics, 107(2), 353-359. https://doi.org/10.1016/j.ijrobp.2020.02.020
Siddiqui, I. A., Sanna, V., Ahmad, N., Sechi, M., &Mukhtar, H. (2015). Resveratrol nanoformulation for cancer prevention and therapy. Annals of the New york Academy of Sciences, 1348(1), 20-31. https://doi.org/10.1111/nyas.12811
Smith, M. T., Guyton, K. Z., Gibbons, C. F., Fritz, J. M., Portier, C. J., Rusyn, I., ...&Straif, K. (2016). Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Environmental health perspectives, 124(6), 713-721. https://doi.org/10.1289/ehp.1509912
Suarez-Torres, J. D., Jimenez-Orozco, F. A., &Ciangherotti, C. E. (2020). The 2-year rodent bioassay in drug and chemical carcinogenesis testing: sensitivity, according to the framework of carcinogenic action. Toxicology Mechanisms and Methods, 30(6), 462-475. https://doi.org/10.1080/15376516.2020.1760986
Trosko, J. E. (2019). What Can Chemical Carcinogenesis Shed Light on the LNT Hypothesis in Radiation Carcinogenesis?. Dose-Response, 17(3), 1559325819876799. https://doi.org/10.1177/1559325819876799
Turner, M. C., Andersen, Z. J., Baccarelli, A., Diver, W. R., Gapstur, S. M., Pope III, C. A., ... & Cohen, A. (2020). Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations. CA: a cancer journal for clinicians, 70(6), 460-479.
https://doi.org/10.3322/caac.21632
Vijg, J., & Dong, X. (2020). Pathogenic mechanisms of somatic mutation and genome mosaicism in aging. Cell, 182(1), 12-23. https://doi.org/10.1016/j.cell.2020.06.024
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