Assessment of Physiological/Toxicological Effects of Camel Milk and Urine on Wistar Rats: A Study on Weight Gain, Haematological, Biochemical, and Histopathological Changes




Camel milk, camel urine, weight gain, Haemobiochemical parameters, Wistar rats


Study’s Excerpt/Novelty

  • This study comprehensively evaluates the physiological effects of camel milk and urine on Wistar rats, providing new insights into their safety and potential health benefits.
  • It uniquely demonstrates that while camel milk and urine independently show some positive physiological impacts, their combination may induce adverse effects, particularly evident through significant changes in body weight, blood parameters, and histopathological lesions.
  • The findings highlight the importance of assessing the safety and efficacy of traditional remedies in isolation and combination, contributing valuable data to the field of ethnopharmacology and veterinary medicine.

Full Abstract

This experiment was steered to observe the safety evaluation of camel milk and its urine on the physiological indices of experimental rats.  Four groups of twenty Wistar rats each were formed: Group 1 (Control), 2 milk (2 ml/100 g), 3 (2 ml/100 g), and 4 (milk/urine combination).  The result showed that all treatment groups experienced a significantly decreased body weight gain across day 1-14, which significantly increased between day 18-21, except for group 4, which decreased significantly.  The PVC, RBC, and haemoglobin increased non-significantly in group 2 and decreased in groups 3 and 4.  WBC decreased significantly in milk/urine combination compared to other treatment groups.  Neutrophils, Lymphocytes, and Monocytes did not show significant alteration across all the treatment groups.  ALT decreased non-significantly (p>0.05) in all the treatment groups, while AST showed non-significant increased values in groups 2 and 3 except in group 4, which decreased significantly.  Urea and creatinine decreased significantly (p<0.05) in all the treatment groups.  Cl- of group 3 decreased significantly (p<0.05), while it increased significantly (p<0.05) in group 4.  Na+ showed significantly increased values across all the treatment groups while Bicarbonate decreased significantly in all the treatments.  Ca2+ increased non-significantly.  Histopathology results showed that group 4 has arrays of lesions compared to those treated separately.  There was no observable lesion in these organs in group-2.  It can be concluded that camel milk and its urine might have some beneficial effects when dosed separately, but they might predispose to harmful effects when combined.


Abdelzaher, H. M., Alsuhaymi, M., Alshammari, F. M., Alshammari, S. A., and Alshammari, Z. M. (2020). Evaluation of the effectiveness of virgin camel's urine as antifungal agents. Journal of Bacteriology and Mycology: 8(1), 124-128.

Adeola, M. O. (1992). Importance of wild animals and their parts in the culture, religious festivals and traditional medicine in Nigeria. Environmental Conservation, 19(2), 125-134.

Al-Anazi, M. S., El-Zahar, K. M., & Rabie, N. A. H. (2022). Nutritional and Therapeutic Properties of Fermented Camel Milk Fortified with Red Chenopodium quinoa Flour on Hypercholesterolemia Rats. Molecules, 27(22), 7695.

Al-Beltagi, M., Saeed, N. K., Bediwy, A. S., Elbeltagi, R., & Alhawamdeh, R. (2023). Role of gastrointestinal health in managing children with autism spectrum disorder. World Journal of Clinical Pediatrics, 12(4), 171.

Ali, A., Baby, B., & Vijayan, R. (2019). From desert to medicine: A review of camel genomics and therapeutic products. Frontiers in Genetics, 10, 17.

Alkhamees, O. A., and Alsanad, S. M. (2017). A review of the therapeutic characteristics of camel urine. African Journal of Traditional, Complementary and Alternative Medicines, 14(2), 120-126.

AL-Moosawi, Z. H., Almahdawi, M. K., & Al-Charak, A. G. (2023). Camel milk as an integrated food and its physical and chemical properties with therapeutic characteristics. International Journal of Veterinary Science and Animal Husbandry, 8, 90-96.

Alves, R., and Rosa, I. (2005). Why study the use of animal products in traditional medicines? Journal of Ethnobiology and Ethnomedicine, 1, 5.

Al-Yousef, N., Gaafar, A., & Al-Otaibi, B. (2012). Camel urine components display anti-cancer properties in vitro. Journal of Ethnopharmacology, 143(3), 819-825.

Aremu A, Oridupa O. A, Akorede G.J, Basiru A, Suleiman K.Y, Ahmed O. A. and Raufu I. A. (2022): Fractions of Lawsonia inermis Linn leaves improved the histomorphological appearance of major organs involved in diabetic complications. Journal of Sustainable Veterinary and Allied Science. 2:(1-6): 136-139

Aremu, A., Oridupa, A. O., Basiru, A., Akorede, G. J., & Ahmed, O. A. (2023). Safety evaluation of bioactive sub-fraction of Lawsonia inermis Linn. leaves in male Wistar rats. Sahel Journal of Veterinary Sciences, 20(1), 22-27.

Bakhsh, R. S., Turkistani, S. A., Felemban, S. G., & Al-Hejin, A. M. (2023). The Effect of Camel Products Against Microbial Infections: A Systematic Review Literature. Advances in Environmental Biology, 17(5), 1-9.

Deyrup, S. T., Stagnitti, N. C., Perpetua, M. J., & Wong-Deyrup, S. W. (2021). Drug discovery insights from medicinal beetles in traditional Chinese medicine. Biomolecules & therapeutics, 29(2), 105.

El-Aziz, A., Kassem, J. M., Aasem, F. M., & Abbas, H. M. (2022). Physicochemical properties and health benefits of camel milk and its applications in dairy products: A review. Egyptian Journal of Chemistry, 65(5), 101-118.

Glencross, B. D., Baily, J., Berntssen, M. H., Hardy, R., MacKenzie, S., & Tocher, D. R. (2020). Risk assessment of the use of alternative animal and plant raw material resources in aquaculture feeds. Reviews in Aquaculture, 12(2), 703-758.

Ibrahim, M., Rehman, K., Razzaq, A., Hussain, I., Farooq, T., Hussain, A., & Akash, M. S. H. (2018). Investigations of phytochemical constituents and their pharmacological properties isolated from the genus Urtica: critical review and analysis. Critical Reviews™ in Eukaryotic Gene Expression, 28(1).

Konuspayeva, G., Faye, B., & Loiseau, G. (2009). Fatty acid and cholesterol composition of camel's (Camelus bactrianus, Camelus dromedarius and hybrids) milk in Kazakhstan. Dairy Science and Technology, 88(3), 327-340.


Mensah, M. L., Komlaga, G., Forkuo, A. D., Firempong, C., Anning, A. K., & Dickson, R. A. (2019). Toxicity and safety implications of herbal medicines used in Africa. Herbal medicine, 63(5), 1992-0849.

Mok, C. K. P., Zhu, A., Zhao, J., Lau, E. H., Wang, J., Chen, Z., Zhuang, Z., Wang, Y., Alshukairi, A. N., & Baharoon, S. A. (2021). T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: An observational cohort study. The Lancet Infectious Diseases, 21(3), 385-395.

Swelum, A. A., El-Saadony, M. T., Abdo, M., Ombarak, R. A., Hussein, E. O., Suliman, G., ... & Abd El-Hack, M. E. (2021). Nutritional, antimicrobial and medicinal properties of Camel’s milk: A review. Saudi Journal of Biological Sciences, 28(5), 3126-3136.

World Health Organization. (2019). WHO global report on traditional and complementary medicine 2019. World Health Organization.

Yadav, A. K., Kumar, R., Priyadarshini, L., & Singh, J. (2015). Composition and medicinal properties of camel milk: A review. Asian Journal of Dairy and Food Research, 34(2), 83-91.




How to Cite

Aremu, A., Oderinde, H. M., Akorede, G. J., Olatunji, A. O., Basiru, A., & Ahmed, A. O. (2024). Assessment of Physiological/Toxicological Effects of Camel Milk and Urine on Wistar Rats: A Study on Weight Gain, Haematological, Biochemical, and Histopathological Changes. UMYU Scientifica, 3(3), 31–37.