Nanoemulsion Drug Delivery Systems for Dermatological Disorders: A Review of Mechanisms, Clinical Applications and Commercial Advances
DOI:
https://doi.org/10.56919/usci.2542.019Keywords:
Skin Delivery, Drug Penetration, Topical Treatment, Azelaic Acid, Zeta PotentialAbstract
Study’s Excerpt:
• Recent developments in nanoemulsion systems for both superficial and deep-skin applications was reviewed.
• It uniquely synthesizes clinical translation barriers, regulatory gaps, and emerging trends like nanoemulgels.
• Multiple complementary approaches across primary databases were employed.
• Nanoemulsions enhance drug permeability with improvements ranges to over 39-fold compared to conventional creams.
• Further clinical studies remain necessary to confirm long-term safety.
Full Abstract:
Objective: This review explores recent developments in nanoemulsion systems for both superficial and deep-skin applications, uniquely synthesizing clinical translation barriers, regulatory gaps, and emerging trends like nanoemulgels.
Methods: A comprehensive narrative review was conducted using multiple complementary approaches across primary databases (PubMed, ScienceDirect) and secondary sources (Google Scholar). Enhanced search capabilities through Elicit and Research Rabbit were utilized to map relevant literature connections. Primary search terms included "nanoemulsion drug delivery," "dermatological applications," "skin penetration enhancement," and "topical nanoemulsions." The review focused on literature from 2019-2024 with strategic inclusion of foundational papers, encompassing original research, clinical studies, and review articles.
Results: Nanoemulsions enhance drug permeability with improvements ranging from several-fold to over 39-fold compared to conventional creams through fluidizing or altering the stratum corneum's lipid matrix, improving solubility, stability, and bioavailability. Critical characteristics such as droplet size and zeta potential determine stability and skin absorptivity, enabling targeted delivery of anti-inflammatory agents and active ingredients while reducing systemic side effects compared to conventional treatments. Despite showing a favourable safety and non-irritant profile, the analysis revealed significant clinical translation barriers and regulatory gaps that limit widespread adoption.
Conclusion: Further clinical studies remain necessary to confirm long-term safety. Future integration with wearables and smart delivery systems may revolutionize dermatological treatment paradigms, positioning nanoemulsions as a transformative technology in topical therapeutics.
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